Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 13 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Aquamin®)
80 mg
6%
UC-II® Standardized Chicken Cartilage(Providing 10 mg Total Collagen, including Undenatured Type II Collagen)
40 mg
†
Aquamin® (Seaweed Derived Minerals) (Lithothamnium spp.) (Whole Plant)
250 mg
†
Top Medical Research Studies
8
Collagen source shows varying effectiveness
We explored the beneficial effects of collagen hydrolysate derived from salmon skin on atherosclerosis, a key contributor to cardiovascular diseases. The study showed that this collagen extract exhibits promising anti-inflammatory and antioxidant properties.
In tests with mice, it effectively reduced arterial thickening and plaque formation without side effects, comparable to the effects of aspirin. However, the results indicate that while collagen from salmon skin has potential, more research is needed before making definitive claims.
In tests with mice, it effectively reduced arterial thickening and plaque formation without side effects, comparable to the effects of aspirin. However, the results indicate that while collagen from salmon skin has potential, more research is needed before making definitive claims.
Read More
8
Collagen supplements may reduce cardiovascular risks
We explored the impact of collagen peptide supplementation (CPS) on cardiovascular disease markers through a careful review of randomized, placebo-controlled trials. Our analysis of twelve studies found that CPS had promising effects, including a decrease in harmful LDL cholesterol and systolic blood pressure, as well as reductions in fat mass.
However, we're clear that CPS did not show any significant effects on blood sugar levels. While these findings are encouraging, further research on CPS with longer durations is needed to fully understand its potential benefits for cardiovascular health.
However, we're clear that CPS did not show any significant effects on blood sugar levels. While these findings are encouraging, further research on CPS with longer durations is needed to fully understand its potential benefits for cardiovascular health.
Read More
8
We explored the potential of collagen hydrolysates from fish skin to impact cardiovascular health, particularly their antiplatelet activity. Eleven peptides were isolated, and nine displayed a Pro-Gly or Hyp-Gly sequence that effectively inhibited platelet aggregation in lab tests. Among these, OGSA showed the strongest effects without increasing bleeding risks. With molecular docking studies suggesting interactions with specific receptors, these peptides may hold promise as dietary supplements for cardiovascular disease prevention.
Read More
Most Useful Reviews
9
Joint restoration
8 people found this helpful
Type II collagen is crucial for joint health, involved in the structure of cartilage and intervertebral discs. With age, collagen decreases. This supplement aids in breaking down and regenerating collagen effectively, thus helping counter joint diseases. I take it on an empty stomach and have faced no side effects, with my knee pain now resolved.
Read More
9
Shoulder improvement
1 people found this helpful
Very good! My husband has degenerative disease in his shoulders and could not raise his arm. After less than a month of usage, he noticed considerable improvement.
Read More
9
Joint comfort
I am delighted to share my positive experience with NOW Foods UC-II Joint Health. Since adding this supplement into my routine, I have noticed significant improvements in joint comfort and mobility. UC-II's efficacy, backed by scientific research, allows me to engage in physical activities with more ease and resilience. It is gentle on the stomach, free from allergens, and a reliable choice for those focused on joint health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
- All Researches
9
We examined the potential of collagen-derived peptides from salmon to combat heart disease, specifically atherosclerosis, in a study involving ApoE mice.
Our findings showed that the peptide OGEFG (OG-5) effectively reduced platelet aggregation and thrombosis by targeting specific receptors and signaling pathways. Additionally, it demonstrated anti-inflammatory effects and decreased atherosclerotic plaque formation compared to traditional treatments like aspirin.
Overall, collagen hydrolysates appear to be a promising dietary supplement for heart health.
Our findings showed that the peptide OGEFG (OG-5) effectively reduced platelet aggregation and thrombosis by targeting specific receptors and signaling pathways. Additionally, it demonstrated anti-inflammatory effects and decreased atherosclerotic plaque formation compared to traditional treatments like aspirin.
Overall, collagen hydrolysates appear to be a promising dietary supplement for heart health.
Read More
8
Collagen source shows varying effectiveness
We explored the beneficial effects of collagen hydrolysate derived from salmon skin on atherosclerosis, a key contributor to cardiovascular diseases. The study showed that this collagen extract exhibits promising anti-inflammatory and antioxidant properties.
In tests with mice, it effectively reduced arterial thickening and plaque formation without side effects, comparable to the effects of aspirin. However, the results indicate that while collagen from salmon skin has potential, more research is needed before making definitive claims.
In tests with mice, it effectively reduced arterial thickening and plaque formation without side effects, comparable to the effects of aspirin. However, the results indicate that while collagen from salmon skin has potential, more research is needed before making definitive claims.
Read More
8
Collagen supplements may reduce cardiovascular risks
We explored the impact of collagen peptide supplementation (CPS) on cardiovascular disease markers through a careful review of randomized, placebo-controlled trials. Our analysis of twelve studies found that CPS had promising effects, including a decrease in harmful LDL cholesterol and systolic blood pressure, as well as reductions in fat mass.
However, we're clear that CPS did not show any significant effects on blood sugar levels. While these findings are encouraging, further research on CPS with longer durations is needed to fully understand its potential benefits for cardiovascular health.
However, we're clear that CPS did not show any significant effects on blood sugar levels. While these findings are encouraging, further research on CPS with longer durations is needed to fully understand its potential benefits for cardiovascular health.
Read More
8
We explored the potential of collagen hydrolysates from fish skin to impact cardiovascular health, particularly their antiplatelet activity. Eleven peptides were isolated, and nine displayed a Pro-Gly or Hyp-Gly sequence that effectively inhibited platelet aggregation in lab tests. Among these, OGSA showed the strongest effects without increasing bleeding risks. With molecular docking studies suggesting interactions with specific receptors, these peptides may hold promise as dietary supplements for cardiovascular disease prevention.
Read More
8
We investigated how Brazilian propolis (AF-08), rich in flavonoids, influences platelet aggregation and its potential role in preventing cardiovascular diseases (CVDs).
Our findings revealed that AF-08 effectively inhibited collagen-induced platelet aggregation without impacting blood coagulation processes.
This suggests that AF-08 may lower the risk of CVDs by preventing harmful platelet clumping while leaving normal blood clotting untouched. Notably, the flavonoids apigenin and chrysin showed significant effects, while kaempferol was less potent.
Our findings revealed that AF-08 effectively inhibited collagen-induced platelet aggregation without impacting blood coagulation processes.
This suggests that AF-08 may lower the risk of CVDs by preventing harmful platelet clumping while leaving normal blood clotting untouched. Notably, the flavonoids apigenin and chrysin showed significant effects, while kaempferol was less potent.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Joint restoration
8 people found this helpful
Type II collagen is crucial for joint health, involved in the structure of cartilage and intervertebral discs. With age, collagen decreases. This supplement aids in breaking down and regenerating collagen effectively, thus helping counter joint diseases. I take it on an empty stomach and have faced no side effects, with my knee pain now resolved.
Read More
9
Shoulder improvement
1 people found this helpful
Very good! My husband has degenerative disease in his shoulders and could not raise his arm. After less than a month of usage, he noticed considerable improvement.
Read More
9
Joint comfort
I am delighted to share my positive experience with NOW Foods UC-II Joint Health. Since adding this supplement into my routine, I have noticed significant improvements in joint comfort and mobility. UC-II's efficacy, backed by scientific research, allows me to engage in physical activities with more ease and resilience. It is gentle on the stomach, free from allergens, and a reliable choice for those focused on joint health.
Read More
9
Reduced hip pain
Excellent! When I take my Uc2 collagen, I soon feel my hip pain decreasing. I can't do without it due to my autoimmune disease.
Read More
9
Knee pain relief
Very effective! My knee pain is gone after eating. Due to degenerative arthritis, the pain in my knee joint has gradually eased and nearly disappeared, allowing for relaxed walking.
Read More
Frequently Asked Questions
9
Shoulder improvement
1 people found this helpful
Very good! My husband has degenerative disease in his shoulders and could not raise his arm. After less than a month of usage, he noticed considerable improvement.
9
Knee pain relief
Very effective! My knee pain is gone after eating. Due to degenerative arthritis, the pain in my knee joint has gradually eased and nearly disappeared, allowing for relaxed walking.
7.5
Noticeable support
Good! I am currently exploring products to support joint health and trying different supplements. NOW Foods, UC-II has a good composition and manufacturer. After two months, I feel an improvement in walking ease.
7
Back pain relief
5 people found this helpful
Works for me. I have been using this for the past six months and have not experienced any issues with my back like I used to. This seems to be easing the discomfort from my deteriorated disk in my back.
9
Joint restoration
8 people found this helpful
Type II collagen is crucial for joint health, involved in the structure of cartilage and intervertebral discs. With age, collagen decreases. This supplement aids in breaking down and regenerating collagen effectively, thus helping counter joint diseases. I take it on an empty stomach and have faced no side effects, with my knee pain now resolved.
9
Reduced hip pain
Excellent! When I take my Uc2 collagen, I soon feel my hip pain decreasing. I can't do without it due to my autoimmune disease.
6
Slight relief
1 people found this helpful
I took it for my mother who has joint problems. It eased her condition slightly. Following the instructions, I gave her 1 capsule per day. Perhaps I should have administered it for a longer duration.
9
Rejuvenated joints
1 people found this helpful
For strong and flexible joints, I take this supplement alongside other joint care ones like chondroitin sulphate, glucosamine, and hyaluronic acid. I have forgotten about joint pains through this twice-a-year course.
7.5
Effective supplement
NON-DENATURED COLLAGEN! The best form of articular collagen. I purchase it regularly for a patient with rheumatoid arthritis. It's an effective additive for all forms of collagen diseases.
8
Collagen source shows varying effectiveness
We explored the beneficial effects of collagen hydrolysate derived from salmon skin on atherosclerosis, a key contributor to cardiovascular diseases. The study showed that this collagen extract exhibits promising anti-inflammatory and antioxidant properties.
In tests with mice, it effectively reduced arterial thickening and plaque formation without side effects, comparable to the effects of aspirin. However, the results indicate that while collagen from salmon skin has potential, more research is needed before making definitive claims.
In tests with mice, it effectively reduced arterial thickening and plaque formation without side effects, comparable to the effects of aspirin. However, the results indicate that while collagen from salmon skin has potential, more research is needed before making definitive claims.
8
Collagen supplements may reduce cardiovascular risks
We explored the impact of collagen peptide supplementation (CPS) on cardiovascular disease markers through a careful review of randomized, placebo-controlled trials. Our analysis of twelve studies found that CPS had promising effects, including a decrease in harmful LDL cholesterol and systolic blood pressure, as well as reductions in fat mass.
However, we're clear that CPS did not show any significant effects on blood sugar levels. While these findings are encouraging, further research on CPS with longer durations is needed to fully understand its potential benefits for cardiovascular health.
However, we're clear that CPS did not show any significant effects on blood sugar levels. While these findings are encouraging, further research on CPS with longer durations is needed to fully understand its potential benefits for cardiovascular health.
9
We examined the potential of collagen-derived peptides from salmon to combat heart disease, specifically atherosclerosis, in a study involving ApoE mice.
Our findings showed that the peptide OGEFG (OG-5) effectively reduced platelet aggregation and thrombosis by targeting specific receptors and signaling pathways. Additionally, it demonstrated anti-inflammatory effects and decreased atherosclerotic plaque formation compared to traditional treatments like aspirin.
Overall, collagen hydrolysates appear to be a promising dietary supplement for heart health.
Our findings showed that the peptide OGEFG (OG-5) effectively reduced platelet aggregation and thrombosis by targeting specific receptors and signaling pathways. Additionally, it demonstrated anti-inflammatory effects and decreased atherosclerotic plaque formation compared to traditional treatments like aspirin.
Overall, collagen hydrolysates appear to be a promising dietary supplement for heart health.
8
We explored the potential of collagen hydrolysates from fish skin to impact cardiovascular health, particularly their antiplatelet activity. Eleven peptides were isolated, and nine displayed a Pro-Gly or Hyp-Gly sequence that effectively inhibited platelet aggregation in lab tests. Among these, OGSA showed the strongest effects without increasing bleeding risks. With molecular docking studies suggesting interactions with specific receptors, these peptides may hold promise as dietary supplements for cardiovascular disease prevention.
References
- Liu H, Yang Y, Liu Y, Cui L, Fu L, et al. Various bioactive peptides in collagen hydrolysate from salmo salar skin and the combined inhibitory effects on atherosclerosis in vitro and in vivo. Food Res Int. 2022;157:111281. 10.1016/j.foodres.2022.111281
- Jalili Z, Jalili F, Moradi S, Bagheri R, Moosavian SP, et al. Effects of collagen peptide supplementation on cardiovascular markers: a systematic review and meta-analysis of randomised, placebo-controlled trials. Br J Nutr. 2023;129:779. 10.1017/S0007114522001301
- Yang Y, Liu H, Cui L, Liu Y, Fu L, et al. A Collagen-Derived Oligopeptide from Salmo salar Collagen Hydrolysates Restrains Atherogenesis in ApoE Mice via Targeting P Y Receptor. Mol Nutr Food Res. 2022;66:e2200166. 10.1002/mnfr.202200166
- Tian Q, Li SM, Li B. The Pro-Gly or Hyp-Gly Containing Peptides from Absorbates of Fish Skin Collagen Hydrolysates Inhibit Platelet Aggregation and Target PY Receptor by Molecular Docking. Foods. 2021;10. 10.3390/foods10071553
- Sugita C, Yamashita A, Tsutsumi S, Kai H, Sonoda T, et al. Brazilian propolis (AF-08) inhibits collagen-induced platelet aggregation without affecting blood coagulation. J Nat Med. 2021;75:975. 10.1007/s11418-021-01518-w
